Peter MacCallum Cancer Centre

Site

Department of Pathology

Accreditation No.

2465

Site No.

2458

Date of Accreditation

14 Sep 1988

Address

Victorian Comprehensive Cancer Centre (VCCC), 305 Grattan Street
Melbourne, VIC 3000
Australia

petermac.org

Contact

Availability

Services available to external clients

Supervision

GX (General)

Scope of Accreditation

ISO 15189 (2012)

Human Pathology

Medicare expiry date

08 Sep 2024

Last Activity Date

16 Mar 2021

Service Product Determinant
Anatomical pathology - Cytopathology - Immunocytochemical investigation (on non-paraffin embedded cellular preparations) Fixed cytological smears Detection of antigenic targets - Various
Anatomical pathology - Cytopathology - Non-gynaecological cytological investigations of body fluids, exudates, washings and brushings from non-squamous mucosal sites for the detection of malignancy Cerebrospinal fluid (CSF); Other body fluids; Sputum; Urine; Washings or brushings from other sites Cytological examination; Review and reporting of cytology samples
Anatomical pathology - Cytopathology - Non-gynaecological cytological investigations of nipple discharge or smears from squamous mucosal sites for the detection of cancerous or precancerous changes Nipple discharge Cytological examination; Review and reporting of cytology samples
Anatomical pathology - Cytopathology - Non-gynaecological cytological investigations on samples obtained via fine needle aspiration biopsy Fine needle aspirates (FNA) Cytological examination; Review and reporting of fine needle aspiration samples
Chemical pathology - Detection and/or quantitation of drugs for therapeutic monitoring Plasma; Serum Methotrexate; Vancomycin
Chemical pathology - Detection and/or quantitation of tumour markers Plasma; Serum Chromagranin A - Gen I
CA125 antigen (CA125); CA15-3 antigen (CA15-3); CA19-9 antigen (CA19-9); Carcinoembryonic antigen (CEA); Human chorionic gonadotropin (hCG); Prostate specific antigen (PSA); α-Fetoprotein (AFP); β2-Microglobulin (B2M)
Chemical pathology - Determination of hormones and hormone binding proteins (other than thyroid function tests) Plasma; Serum Cortisol; Follicle stimulating hormone (FSH); Luteinising hormone (LH); Oestradiol; Progesterone; Prolactin; Testosterone
Chemical pathology - Diagnosis and management of diabetes mellitus Blood Glycated haemoglobin (HbA1c)
Chemical pathology - Further investigation of cardiac function Plasma; Serum Troponin I
Serum N-Terminal-pro b-type natriuretic peptide (NT-proBNP)
Chemical pathology - Further investigation of lipid profiles for diagnosis of types III and IV hyperlipidaemia Plasma; Serum HDL - Quantitation
Chemical pathology - Further investigation of renal and/or hepatic function Plasma; Serum Haptoglobins
Chemical pathology - Investigation and determination of hepatic, cardiac, bone, skeletal muscle and other profiles and metabolic studies Cerebrospinal fluid (CSF) Glucose; Protein - Total
Other body fluids Amylase; Glucose; Lipase; Protein - Total
Plasma; Serum Alanine aminotransferase; Albumin; Alkaline phosphatase; Amylase; Aspartate aminotransferase; Bicarbonate; Bilirubin - Any fractions; Bilirubin - Total; C-reactive protein (CRP); Calcium - Total; Chloride; Cholesterol - Total; Cholinesterase; Creatine kinase; Creatinine; Glucose; Lactate dehydrogenase (LDH); Lipase; Magnesium; Phosphate; Potassium; Protein - Total; Sodium; Triglycerides; Urate; Urea; γ-Glutamyltransferase
Urine Chloride; Creatinine; Potassium; Protein - Total; Sodium
Chemical pathology - Investigation for folate deficiency Blood; Serum Folate; Red blood cell folate
Chemical pathology - Iron studies Plasma; Serum Ferritin; Iron; Transferrin
Chemical pathology - Quantitation of blood gases and other measurements (performed on the same specimen) Blood Calcium - Ionised; Carboxyhaemoglobin; Chloride; Glucose; Haemoglobin (Hb); Lactate; Methaemoglobin (MetHb); Oxyhaemoglobin; Partial pressure of carbon dioxide (pCO2); Partial pressure of oxygen (PO2); Potassium; Sodium; pH
Chemical pathology - Quantitation of vitamins Plasma; Serum Cobalamin (vitamin B12); Vitamin D
Chemical pathology - Tests for thyroid function Plasma; Serum Thyroid stimulating hormone (TSH); Thyroxine (T4) - Free; Triiodothyronine (T3) - Free
Clinical governance - Level 2 - Designated person assessment Not applicable Not applicable
Haematology - Bone marrow examination Bone marrow Examination of aspirated material
Haematology - Examination of blood films by special staining Blood; Bone marrow Non-specific esterase
Haematology - Full blood examination Blood Differential number; Erythrocyte count (red blood cell count, RBCC); Haematocrit (packed cell volume, PCV); Haemoglobin (Hb); Leucocyte count (white blood cell count, WBCC); Mean platelet volume (MPV); Morphology; Nucleated red blood cells (NRBC); Platelet count; Red blood cell distribution width (RDW); Red blood cell index or indices; Reticulocytes
Haematology - Haemostasis related analysis (including special coagulation testing and platelet function tests) Blood; Plasma Activated partial thromboplastin time (APTT); Anti-Xa activity; Anti-thrombin III; D-dimer; Factor VIII; Fibrinogen; Prothrombin time (PT); Thrombin time (TT); Viscoelastic haemostatic testing (VHT); Von Willebrand factor (vWF)
Haematology - Investigation of haemolysis Blood; Plasma Cold agglutinins
Immunohaematology - Blood group antibody detection Blood; Plasma Duffy system; Kell system; M and N factors; Other blood group systems; Rh phenotypes
Immunohaematology - Blood grouping Blood ABO; RhD
Immunohaematology - Determination of compatibility of blood donor units Blood Direct antiglobulin test (DAT, direct Coombs test); Examination for blood group antibodies; Group checks of patient and donor; Identification of detected antibodies
Immunohaematology - Identification and quantitation of blood group antibodies Blood; Plasma Other blood group antibodies
Antibody absorption; Antibody elution; Antibody titration; Other blood group antibodies; Red blood cell phenotyping; Rh
Antibody absorption; Antibody elution; Red blood cell phenotyping
Immunohaematology - Investigation of blood transfusion reactions Blood products Antibodies
Immunohaematology - Issue and release of blood and blood product for transfusion Blood; Fresh frozen plasma (FFP); Platelets Issue and release of blood and blood products for transfusion
Immunopathology - Characterisation of leucocyte surface antigens (including immunophenotyping) Blood CD34
Blood; Bone marrow; Disaggregated tissues specimen; Fresh tissue Assessment of lymphoid cell populations; Assessment of myeloid cell populations; CD10; CD103; CD117; CD11b; CD11c; CD13; CD138; CD14; CD15; CD16; CD19; CD1a; CD2; CD20; CD22; CD23; CD25; CD27; CD28; CD3; CD33; CD34; CD38; CD4; CD45; CD5; CD56; CD64; CD7; CD79αcy; CD8; HLA-DR antigen; Kappa light chains; Lambda light chains; Myeloperoxidase; Terminal deoxynucleotidyl transferase (TdT); Total leucocyte number; Total lymphocycte number; Viable cell count
Blood; Bone marrow; Disaggregated tissues specimen; Fresh tissue; Serous fluid Assessment of lymphoid cell populations; Assessment of myeloid cell populations
Immunopathology - Quantitative and/or qualitative investigation of proteins Serum; Urine Detection and quantitation of free kappa and free lambda light chains
Characterisation of paraproteins; Detection and amount of paraproteins
Immunopathology - Quantitative investigations of immunoglobulins and immunoglobulins subclasses Plasma; Serum Total immunoglobulin A; Total immunoglobulin G; Total immunoglobulin M
Immunopathology - Tests of cellular immunity - Lymphocyte function tests Blood T-cell subsets
Infertility and pregnancy tests including assisted reproductive technology - Diagnosis of pregnancy Serum; Urine Detection of human chorionic gonadotropin (hCG)

ISO 15189 (2012)

Human Pathology

Medicare expiry date

08 Sep 2024

Last Activity Date

16 Mar 2021

Service Product Determinant
Anatomical pathology - Cytopathology - Gynaecological (non-cervical) cytological investigation for abnormalities, precancerous or cancerous changes or conditions Vulval smears Cytological examination; Review and reporting of gynaecological (non-cervical tissue) cytological samples
Anatomical pathology - Tissue pathology - Examination of biopsy material Formalin fixed tissue; Fresh tissue Review and reporting of biopsy material to identify or exclude morphological abnormalities
Anatomical pathology - Tissue pathology - Gene probes using paraffin fluorescence in-situ hybridisation (FISH) Formalin fixed paraffin embedded tissue sections Detection of nucleic acid targets - Various
Anatomical pathology - Tissue pathology - Gene probes using paraffin in-situ hybridisation techniques (chromogenic/silver) Formalin fixed paraffin embedded tissue sections Detection of nucleic acid targets - Various
Anatomical pathology - Tissue pathology - Immediate frozen section diagnosis Fresh tissue; Smears; Tissue imprint Intra-operative consultation and examination of biopsy material
Anatomical pathology - Tissue pathology - Immunohistochemical (immunofluorescence) investigation Fresh tissue; Frozen tissue Detection of antigenic targets - Various
Anatomical pathology - Tissue pathology - Immunohistochemical investigation Formalin fixed paraffin embedded tissue sections; Fresh tissue; Frozen sections of fresh tissue Detection of antigenic targets - Various

ISO 15189 (2012)

Human Pathology

Medicare expiry date

08 Sep 2024

Last Activity Date

16 Mar 2021

Service Product Determinant
Molecular genetics - Assay for defined mutation or polymorphism (including pharmacogenetic testing) - Targeted genes Blood; Bone marrow Acute myeloid leukaemia RUNX1; Nucleophosmin 1 (NPM1) mutated AML
Blood; Bone marrow; Formalin fixed paraffin embedded tissue sections; Tissues Blood borne tumours
Formalin fixed paraffin embedded tissue sectionsctDNA Solid tumours
Molecular genetics - Bioinformatic analysis DNA sequences; FASTQ files; RNA sequences Primary analysis - Conversion of instrument file to FASTQ or FASTA file; Secondary analysis - Alignment and variant calling; Tertiary analysis - Data annotation and interpretation
Molecular genetics - DNA extraction Blood; Body fluids; Bone marrow; Buccal swabs; Buffy coat; Cultured cells; Formalin fixed paraffin embedded tissue sections; Fresh tissue; Hair; Plasma; Saliva; Tissues DNA storage for future analyses; Purified PCR product; Viable DNA; Viable DNA for sequencing
Molecular genetics - DNA fragment size analysis Blood; Bone marrow; Extracted DNA; Formalin fixed paraffin embedded tissue sections; Tissues Fragment size DNA determination
Molecular genetics - DNA sequencing Blood; Bone marrow; Cultured cells; Extracted DNA; Formalin fixed paraffin embedded tissue sections; Fresh tissue; Hair; Oral fluid; TissuesNULL Sequenced DNA by Sanger sequencing; Sequenced DNA utilising massively parallel sequencing technologies
Molecular genetics - Detection and characterisation of cell free RNA (cfRNA) /cell free DNA (cfDNA)  in cancer screening Plasma Nucleic acid analysis for specific variants
Molecular genetics - Genetic testing for chimerism and mosaic gene variants (cancer and somatic mosaicism) - Targeted genes Blood; Bone marrow Haemopoietic chimerism post allogenic BMTx
Molecular genetics - Investigation of constitutional genetic variants - Diagnostic testing - Targeted genes Blood; Bone marrow; Extracted DNA; Saliva Blood borne tumours; Solid tumours
Molecular genetics - Predictive genetic testing - Targeted panels for inherited (germline) DNA/RNA changes Blood; Extracted DNA; Saliva Inherited solid tumours
Molecular genetics - RNA extraction Blood; Bone marrow; Formalin fixed paraffin embedded tissue sections; Tissues Viable RNA for sequencing
Molecular genetics - RNA sequencing Extracted RNA Sequenced RNA; Sequenced RNA by Sanger sequencing
Molecular genetics - Screening for an unknown mutation - Targeted panels for non-inherited (somatic) DNA/RNA changes Blood; Bone marrow; Formalin fixed paraffin embedded tissue sections; Fresh tissue; Saliva Blood borne tumours; Solid tumours
Formalin fixed paraffin embedded tissue sections; ctDNA Solid tumours
Molecular genetics - Screening for an unknown mutation - Targeted genes Blood; Bone marrow; Formalin fixed paraffin embedded tissue sections Blood borne tumours; Solid tumours
Formalin fixed paraffin embedded tissue sections Solid tumours
Molecular genetics - Screening for an unknown mutation - Targeted panels for inherited (germline) DNA/RNA changes Blood; Extracted DNA; Saliva Nucleic acid analysis for unknown variants

ISO 15189 (2012)

Human Pathology

Medicare expiry date

08 Sep 2024

Last Activity Date

16 Mar 2021

Service Product Determinant
Chemical pathology - Quantitation of blood gases and other measurements (performed on the same specimen) Blood Calcium - Ionised; Carboxyhaemoglobin; Chloride; Glucose; Haemoglobin (Hb); Lactate; Methaemoglobin (MetHb); Oxyhaemoglobin; Partial pressure of carbon dioxide (pCO2); Partial pressure of oxygen (PO2); Potassium; Sodium; pH

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